Don’t let that slick salesman honeyfuggle you: A fancy bombazine will never hold up in this toad-strangler.Say what?Well, it’s certainly English, but few people these days refer to deceitful flattery as honeyfuggle. And unless you’re from Baltimore, you might not know that a bombazine is an umbrella, and only those from the Gulf region would call a sudden, heavy rainstorm a toad-strangler.Just as in England the mother tongue sometimes bears little resemblance to what is spoken in the United States, the provincial vocabularies and dialects of America’s small towns and big cities can sometimes sound like foreign languages to the uninitiated.Cataloging, decoding, and preserving the colorful idioms and terms used by regular folks before they’re lost to history, the Dictionary of American Regional English (DARE) is an acclaimed scholarly text widely referenced by everyone from teachers and librarians to forensic linguists and oral historians.DARE, a project that took nearly 50 years to complete, includes 60,000 entries with not only the expected definitions and parts of speech, but alternate spellings and pronunciations, etymology, geographical origins, as well as synonyms from other areas of the country, quotations to illuminate word usage, and related bibliographies. Maps plot where a word is most often used, based upon the dictionary’s original field research.Soundbytes: Dictionary of American Regional EnglishDARE tape, 1965–70. Quotations from informants as recorded by DARE fieldworkers. Click “View track” above to see a written definition of each word.This week, Harvard University Press (HUP), which publishes DARE, debuts a digital version of the six-volume dictionary, delivering the quirky treasures of our plainspoken language to the laptops of researchers and word nerds everywhere.In addition to an array of advanced searches of the complete text entries, the online DARE offers 4,000 audio clips of words as spoken by those who used them, as well as detailed survey data, mapping functions, and broad demographic information compiled by dictionary researchers. Non-subscribers can sample 100 full entries, including maps and the relevant audio clips.In many ways, the dictionary challenges the conventional wisdom that the gumbo of American English has lost much of its local tang.“It’s a popular notion that American English has become ‘homogenized’ by the mobility of our population and the pervasiveness of national media, so I can understand why people like to believe it,” DARE’s editor in chief, Joan H. Hall, said in an email. “My view is that while language is always in the process of change, it doesn’t change in the same ways or at the same rate in all places. So yes, some local or regional terms may be displaced by terms that take hold nationwide, particularly through advertising, but thousands of others will continue to thrive in their localities, and new regional terms will appear as they fill particular niches.”Hall believes the dictionary helps to legitimize regional terms by putting them in front of a national audience.“DARE makes it clear that American English, while generally shared across the country, still has delightfully different flavors in different places, the result of differences in original settlement histories, later immigration patterns, economic and social differences, urban and rural character, etc. Their inclusion in a work like DARE can instill pride in the people who use them, knowing that they are reflections of our cultural history rather than indicators of backwardness or being out of step,” she said.Native tonguesAssembling an authoritative dictionary of everyday vernacular was no easy task, and the idea dates back more than a century. In the late 1880s, the American Dialect Society sought to create a comprehensive compilation of dialects spoken across the United States, just as linguist Joseph Wright was developing the now-definitive English Dialect Dictionary in England.But gathering information in a country vastly larger than England proved formidable, and the project languished for more than four decades until an English professor at the University of Wisconsin-Madison got tired of waiting. Professor Frederic G. Cassidy started his own trial effort to catalog native dialects and published his findings in the society’s journal in 1953. Jolted by his initiative, the society formally pushed ahead with the nascent Dictionary of American Regional English, naming Cassidy — who later was known to exhort his staffers with “On to Z!” — as its editor in chief in 1962.Between 1965 and 1970, about 80 Wisconsin graduate students rumbled across the country in specially outfitted campers called “word wagons” to conduct face-to-face interviews with lifelong natives in roughly 1,000 communities about the everyday words they used for things such as food and household items and for concepts like money, religion, and marriage.In all, surveyors talked to 2,777 people who answered a 1,600-item questionnaire that took a week to complete, generating 2.3 million responses. Many of those surveyed also agreed to have their voices recorded as they spoke informally with the interviewers and read aloud a passage from the story “Arthur the Rat,” providing a rich trove of audio materials that capture regional, local, and personal syntax, pronunciations, lexicons, and inflections and allow for broad, contrasting analyses.HUP published the dictionary’s first volume, spanning entries A through C, in 1985. The final volume came out last year. A sixth, companion volume that includes supplementary maps that identify the words typifying a particular state or region and lists of the various responses that interviewees gave to survey questions was released last January.Researchers at UW-Madison announced last week that they will start a new round of surveys in those same Wisconsin communities to see how language has changed since the original fieldwork was done there nearly 50 years ago. That effort, to be done online, will be completed in 2015.Major new chapterMore than two years in the planning, the digital DARE marks “a major new chapter” in the dictionary’s history and has been eagerly anticipated by readers and librarians, HUP Director William P. Sisler said in a statement. The press plans to present the finished project to the American Library Association at its midwinter meeting next month.“We intellectually knew that they had a lot of great data and it would be really interesting to do this, but it’s really come out better than we could have hoped,” said Emily Arkin, HUP’s senior editor for digital publication development.The appeal of argot is far broader than one might expect for a specialty dictionary.“There’s certainly a more scholarly audience of people who are lexicographers, dictionary specialists, or linguists. But we also find that it’s really popular for the performing arts — the creative arts in general — and writing,” especially for playwrights, said Arkin.Because of the emphasis on mapping word origins and capturing obscure terminology, Arkin said DARE has been employed for a host of inquiries, such as helping detectives decipher ransom notes or giving families a vivid picture of how their forebears lived and spoke earlier in the 20th century.Even staffers long familiar with the project are frequently delighted by the rich distinctions of American speech.“We never get bored of looking at it,” said Arkin. “It’s so full of really interesting and fun words. We’re always discovering new things in it. ”
Many basic and clinical researchers are testing the potential of a simple and efficient gene editing approach to study and correct disease-causing mutations for conditions ranging from blindness to cancer, but the technology is constrained by a requirement that a certain short DNA sequence be present at the gene editing site.Now investigators at Massachusetts General Hospital (MGH) have modified the system to be nearly free of this requirement, making it possible to potentially target any location across the entire human genome. Their advance is described in Science.The clustered regularly interspaced short palindromic repeat (CRISPR) — associated protein 9 (Cas9) genome editing technology is a defense strategy used by bacteria to make cuts to the DNA of invading viruses.For the CRISPR-Cas9 system to work, a bacterial defense protein called Cas9 seeks out a short region — called a protospacer adjacent motif (or PAM) — that is present in the viral DNA but not in the bacterial DNA. CRISPR-Cas9 has been harnessed for editing the human genome because such PAM sequences are also quite common in our DNA; however, genes that are not near a PAM cannot be targeted.To overcome this hurdle, a team led by Benjamin P. Kleinstiver, a biochemist at MGH’s Center for Genomic Medicine, engineered variants of a Cas9 protein that do not require a specific PAM to bind and cut DNA. The two new Cas9 variants, named SpG and SpRY, allow editing of DNA sequences at efficiencies not achievable with conventional CRISPR-Cas9 enzymes. A crisper CRISPR Related Genome editing with precision Radcliffe symposium examines the rapid advances brought by CRISPR “Because the engineered proteins can target much more freely, they enable targeting of previously inaccessible regions of the genome,” said Kleinstiver. “By nearly completely relaxing the requirement for the enzymes to recognize a PAM, many genome editing applications are now possible. And since nearly the entire genome is targetable, one of the most exciting implications is that that the entire genome is ‘druggable’ from a DNA-editing perspective.”The researchers next plan to better understand the mechanism of how these proteins function, while exploring their unique capabilities for a variety of different applications. In the meantime, they are optimistic that the new Cas9 variants will be a meaningful advance for the genome editing community.“We have demonstrated that these new enzymes will allow researchers to generate biologically and clinically relevant genetic modifications that were previously unfeasible.” said lead author Russell T. Walton, also of MGH’s Center for Genomic Medicine.Additional co-authors of the manuscript from the Kleinstiver laboratory include Kathleen A. Christie, and Madelynn N. Whittaker. Fewer off-target edits and greater targeting scope bring gene editing technology closer to treating human diseases Power and pitfalls of gene editing Prime editing system offers wide range of versatility in human cells, correcting disease-causing genetic variations
The official starting point of the Boston Marathon, the oldest Marathon in the world, is Hopkinton, MA where EMC’s corporate headquarters also sits. The area’s many colleges and universities make Boston an international center of higher education and medicine and a world leader in innovation. It is no wonder then that MassChallenge, the largest-ever startup accelerator, and the first to support high impact, early-stage entrepreneurs with no strings attached, was established here in the “Innovation Waterfront District.” MassChallenge launched a program in Israel with the support of EMC in the spring of 2013 – over 100 startups and 60 judges participated. The program connects the most promising early-stage companies with the resources and networks at the heart of MassChallenge’s Boston accelerator.In the announcement, John Hawthorne, Founder & CEO of MassChallenge said, “MassChallenge Israel features a deep infrastructure of supporters and resources within Israel, strong connections between Israel and Boston, and exclusive opportunities for Israeli startups in Boston… Boston and Israel have had a special relationship for a long time that has generated close collaboration on both business and technological fronts.” MassChallenge selected Israel as its first international location because of the country sits at the cutting edge of technology and entrepreneurial activities globally, and because MassChallenge is eager to enable top startups to scale quickly and effectively.”Understanding the power of this partnership, I partnered with John and his MassChallenge team to create new opportunities for partnerships between our organizations. Initially, I drove EMC‘s global participation in the MassChallenge judging process and inspired local leaders to mentor the 128 finalists.Subsequently, I established and hosted a new program called “Technology Directions: Keeping It Real.” Our first event, held in May 2013 was “Open Source Software – What’s the Buzz All About?” Speakers included leaders from RackSpace and two MassChallenge start-ups: AppSembler and Profit Bricks.Thinking outside the BoxI am not the only one working to extend and grow EMC’s partnership with MassChallenge. EMC’s Executive Business Center (EBC) Director Bernie Baker and his team partnered with me and Steve Todd, EMC VP and Fellow, to develop an EBC customer innovation tour at MassChallenge’ s corporate headquarters. AIG Israel was the first to tour with us and their Israel CIO reflected that “EMC is a brilliant company that is stimulating new initiatives.”But it is not only about customers, it is also about employee enthusiasm and knowledge sharing. Thus, we created an EMC Innovation Ambassador program for employees with different skills, talents, and roles to share their personal innovation stories with customers and partners. The mission of the Innovation Tour is to “envision an inspired creative community where EMC, our customers, and our partners, can collaborate globally around innovation.”MassChallenge Keeps GrowingWhat is truly exciting is to see MassChallenge growing. Some of its supporters include US President Barack Obama, Massachusetts Governor Deval Patrick, venture capitalist Desh Deshpande, Dr. Josh Boger of Alkeus Pharmaceuticals, the Kraft Family, and top brands like Fidelity, Microsoft, and Verizon.Since starting in 2010, the 489 MassChallenge alumni companies have raised $472 million in funding, generated nearly $200 million in revenue, and created nearly 4,000 jobs.In December 2013, MassChallenge and EMC UK & Ireland President James Petter met with UK Prime Minister David Cameron to discuss the launch of a program expansion in the UK. In London, MassChallenge will engage hundreds of startups, expert mentors, investors, students, and business leaders from across the UK, Europe, and the world – placing London at the center of the global innovation map.It has been less than a year since I began engaging with MassChallenge. We have traversed continents to bring the spirit of entrepreneurship outside the walls of our corporate campus in order to catalyze a connected community of innovation and thought leadership.To learn more about MassChallenge, visit their homepage at www.masschallenge.org and consider reading the 2013 MassChallenge Impact Report or reviewing the 2013 winners.
FacebookTwitterLinkedInEmailPrint分享CNN Business:PSEG has relied on fossil fuels to keep the lights on for the past 116 years. Now, New Jersey’s largest and oldest power company is pledging to deliver carbon-free electricity to fight climate change.The $30 billion utility provider announced Thursday that it’s on track to slash carbon emissions by 80% by 2046, compared with 2005 levels. And PSEG, which also serves more than a million customers on Long Island, is setting an ambitious goal of getting down to net-zero carbon emissions by 2050.To get there, the power company is shutting down its coal plants, betting big on offshore wind and working hard to keep its existing nuclear plant alive. PSEG said it won’t build or acquire any new fossil-fueled power plants, including those running on dirt-cheap natural gas.PSEG is joining a growing list of power companies going all-in on the clean energy revolution. The movement reflects the rapid decline in renewable energy costs and a growing push by households, businesses and state governments to respond to the threat of climate change.“We believe climate change is real. There is this crescendo that’s building,” PSEG CEO Ralph Izzo told CNN Business. “Climate change represents the pre-eminent challenge of our generation,” he wrote in a letter to stakeholders announcing the goals. “It’s far past time we moved beyond simply ‘heeding warnings’ to acting on them.”Last month, PSEG announced an agreement to sell its stake in a pair of coal plants in western Pennsylvania. The company plans to shut its final coal-powered unit, located in Connecticut, within 18 months.More: One of America’s oldest power companies is going carbon free New Jersey utility PSEG pledges to be carbon-free by 2050
If you’ve never been to Snowshoe’s mountaintop village, you owe it to yourself to plan a trip this winter – it’s the perfect antidote to all the virtual everythings we’ve been shifting to. And if you have, you’ll remember the cobblestone street village, the night skiing, the shopping, restaurants, and, of course, the Spa. Schussbombing down the mountain not your style? Well, we’re big fans of their winter adventure tours that allow you to tour the mountain and surrounding areas by RzR (snow-ready off-road buggies) horse-drawn sleigh and snowmobiles – to each their own speed. Our friends at Snowshoe are getting pretty excited about the imminent arrival of the first snow. After all, in a year ripe with unforeseen twists and turns, this just might be the best news we’ve heard so far: winter will come. Snow will come. First chairs will come. Last calls will come. Unbridled, uncontained, kick-your-heels-in-the-air fun will come. And Snowshoe’s family of instructors, patrollers, groomers, snow makers, cocktail mixers, lifties, chefs, and countless more, can’t wait to see you return to the mountain. All the best of winter, and all in-person. Opening Day is NOT a virtual event. There will be snow, and lots of it. Guaranteed. Snowshoe is officially dropping their first rope and rolling out the white carpet with lots of fun festivities and their notorious shenanigans on December 4 (weather permitting).Ps: Don’t forget to wear your favorite costume. Snowshoe has been working hard to put policies in place to make sure this season will be both fun AND safe for everyone. Following state, federal, and industry guidelines, Snowshoe’s COVID-19 plan involves daily employee health screenings, physical distancing protocols, and increased sanitation and disinfecting efforts. More details can be found here. According to official sources, this winter will be dominated by La Niña. In other words, above-normal snowfall is expected for West Virginia’s Appalachian Mountains. Yes, that means more pow for everyone, including you. And should Mother Nature go on strike for a week or two, Snowshoe’s recently upgraded array of high-tech snow guns will make good on their unique Snow Guarantee. More details can be found here. Winter Can Never Come Soon Enough A safe and responsible winter season. To get the scoop on the latest deals and to begin planning your trip, start here.
More than 35,000 lives would have been saved in the US if social distancing measures had begun just a week earlier than they actually did in mid-March, according to a new estimate by researchers at Columbia University.They said simulations based on several models showed that 61 percent of the US cases of infection as of May 3 — more than 700,000 — and 55 percent of the more than 65,000 recorded deaths could have been averted if social distancing and other safety measures had been in place a week earlier.These researchers said the simulations illustrate the danger of easing lockdown measures too early, as many experts have noted. All 50 US states have begun to reopen, to one extent or another and with encouragement from President Donald Trump, to try to resurrect economies devastated by business closures and layoffs in the pandemic. The United States is the country hardest hit by the pandemic, with more than 1.5 million cases of infection and more than 93,000 deaths, according to a tally by Johns Hopkins University. “Efforts to further raise public awareness of the ongoing high transmissibility and explosive growth potential of COVID-19 are still needed at this critical time,” the researchers wrote.”Our results also indicate that without sufficient broader testing and contact tracing capacity, the long lag between infection acquisition and case confirmation masks the rebound and exponential growth of COVID-19 until it is well underway,” they said.Ten days ago, a New York documentary filmmaker named Eugene Jarecki set up a billboard in Times Square with what he calls the “Trump Death Clock.” It gives the number of deaths that Jarecki says could have been avoided if Trump had encouraged social distancing practices on March 9, rather than on March 16.His figures are higher than those of the Columbia researchers because Jarecki argues that 60 percent of US deaths could have been averted by acting a week earlier. Topics :
As large-scale social restrictions (PSBB) forced people to stay at home, some women found themselves trapped with abusive partners. The Jakarta chapter of the Legal Aid Foundation of the Indonesian Women’s Association for Justice (LBH APIK Jakarta) alone received 366 reports of domestic violence between March 16 and June 30, an average of 110 reports a month.Read also: House in hot water as critics demand resumption of pro-women bills“Some abusers are able to go free because the regional administration ended their imprisonment because of a lack of testing facilities,” North Sulawesi activist Lily Djenaan said.As women face increased adversity during the pandemic, lawmakers have put women’s issues on the back burner, stalling two long-awaited pieces of legislation: the sexual violence prevention bill and the domestic worker protection bill.The sexual violence prevention bill, first proposed in 2016, was removed from this year’s National Legislation Program (Prolegnas) priority list in July. Lawmakers called deliberation of the bill “too complicated”.“Even before the pandemic, violence against women was rampant,” Women’s Institute (Institut Perempuan) founder Valentina Sagal said. “The state should have prioritized the bill, especially during this pandemic. We need to have laws that show the government’s presence in protecting the victims.”The domestic worker protection bill, which has been under deliberation for even longer (16 years), remains stuck in the House of Representatives Legislative Body (Baleg).“The country does not use a gender-responsive perspective to address the COVID-19 pandemic. That’s one problem among many others in this country’s COVID-19 response,” Asfinawati said. Valentina echoed Asfinawati’s sentiment.“The state needs to include women in its handling of the COVID-19 crisis. Otherwise, the government’s rhetoric of protecting the country will end up neglecting women,” she said.Topics : Health care was one of these fault lines.Lusi Peilouw, an activist from Ambon, Maluku, said that some pregnant women had to pay more for maternal health care because hospitals required patients to undergo COVID-19 swab and rapid tests.“Some women were even denied labor and delivery services by the hospital because their rapid test results came back positive,” she added.The government’s response to the pandemic has also brought unintended consequences for women. The ongoing COVID-19 outbreak in Indonesia continues to disproportionately affect women, exacerbating gender inequalities that were already present in the country, women’s rights activists say.The 40 organizations that belong to the Women’s Awakening Alliance have gathered data on women’s experiences nationwide and have found that the health crisis has intensified existing social and economic inequalities between men and women.“The pandemic has exposed the fault lines on women’s issues in a myriad of ways,” Indonesian Legal Aid Foundation (YLBHI) chairwoman Asfinawati said in a webinar on Sunday.
Siemens Transmission and Distribution is carrying out commissioning works on the recently installed Offshore Transformer Module (OTM) at the Beatrice offshore wind farm in preparation for the energisation of the system.Nexans is working on routing, jointing and termination works on the two export cables, EC1 and EC3, which have been pulled in to the OTM.The walk-to-work vessel Island Crown is at the Beatrice site as the accommodation and support vessel for all works on the OTM.The first of the two OTMs Beatrice will feature (OTM 1) was installed in February.Meanwhile, Seaway Heavy Lifting (SHL) is installing the jacket foundations for the project, whose 84 wind turbines and two OTMs will all be supported by this foundation type. SHL has so far installed 43 out of the total 86 jackets.The first of 84 7MW wind turbines, to be delivered by Siemens Gamesa, are scheduled to be installed this summer. The 588MW offshore wind farm is expected to be operational by the end of 2019.
PERRIS, Calif. – For the second month in a row, extra money will be up for grabs when IMCA Modifieds race at Perris Auto Speedway this Saturday night, Aug. 25.The main event will pay $1,500 to win and is a qualifying event for the 2019 Fast Shafts All-Star Invitational ballot. There will be the $500 “Inland Rigging Fast Car Dash Presented by CP Carillo” and Billy Griffin will award $100 to the fastest Modified qualifier.A $125 Eibach Spring Forward award goes to the hard charger.The Modified feature will be 30 laps. The runner-up earns $600 with $450 paid for third.The grandstand opens at 5 p.m. and racing starts at 7 p.m.
Steven Crook has signed a new two-year contract with Middlesex.Crook played a valuable role in helping his team win the Division Two title, taking 26 wickets at an average of 31.“He had a very good first season and thoroughly deserves this new contract,” said Middlesex director of cricket Angus Fraser.AdChoices广告“With the ball he offers something different as he can bowl very fast, and his pace unsettled many opposing batsmen.“During the season he claimed several top wickets, often dismissing the opposition’s gun batsman.“He is an excellent fielder and dangerous batsman. The encouraging thing is that we firmly believe there is still a lot more to come.”