Turkuaz Rings In 2018 With New Paul McCartney & Wings Cover [Video/Photo]

first_imgFunk powerhouse Turkuaz entered 2018 in style with their annual New Year’s Eve celebration, The Ball Drop! The fan-favorite Brooklyn funk act celebrated New Year’s Eve with fellow funksters, Pimps Of Joytime, with a special performance in Baltimore, Maryland at Rams Head Live on Sunday night. The band played a scorching set to a packed crowd, featuring an exciting mix of originals and covers, including Sly & The Family Stone‘s “Babies Makin’ Babies”, Hot Chocolate‘s “Everyone’s A Winner”, The Bar-Kays‘ “Holy Ghost”, and a new cover of Paul McCartney & Wings‘ “Jet”.Greensky Bluegrass Announce 2 Nights At Red Rocks With Turkuaz & California HoneydropsNow entering 2018, the band is about to jump right into Winter Tour starting with a run of dates leading them into Jam Cruise and hitting some Northeast cities. The second leg of the tour begins with a trek through Colorado and the Pacific Northwest that will include numerous ski towns before heading down the West Coast and ending with two shows opening for Galactic in SF and LA. Dates and ticket info can be found on the band’s website.Watch Turkuaz perform “Jet” by Paul McCartney & Wings on New Year’s Eve below:Check out the setlist below, as well as a full photo gallery from Jim Houle Photography.Setlist: Turkuaz | Rams Head Live | Baltimore, MD | 12/31/17Chatte Lunatique, Percy Thrills The Moondog, Nightswimming, If I Ever Fall Asleep, Babies Makin’ Babies*, On the Run, Everyone’s A Winner^, Lookin’ Tough, Feelin’ Good, European Festivity Nightmare, 20 Dollar Bill, Auld Lang Syne, King Computer, Coast To Coast, Tip Toe Through the Crypto, Jet**, The, Generator, Holy Ghost^^, Future 86, Bubba SlideEncore: Monkey Fingers* Sly & the Family Stone Cover^ Hot Chocolate Cover** Paul McCartney & Wings Cover^^ The Bar-Kays CoverTurkuaz | Rams Head Live | Baltimore, MD | 12/31/17 | Photos by Jim Houle Photography Photo: Jim Houle Load remaining imageslast_img read more

Capabilities of CRISPR gene editing expanded

first_imgMany basic and clinical researchers are testing the potential of a simple and efficient gene editing approach to study and correct disease-causing mutations for conditions ranging from blindness to cancer, but the technology is constrained by a requirement that a certain short DNA sequence be present at the gene editing site.Now investigators at Massachusetts General Hospital (MGH) have modified the system to be nearly free of this requirement, making it possible to potentially target any location across the entire human genome. Their advance is described in Science.The clustered regularly interspaced short palindromic repeat (CRISPR) — associated protein 9 (Cas9) genome editing technology is a defense strategy used by bacteria to make cuts to the DNA of invading viruses.For the CRISPR-Cas9 system to work, a bacterial defense protein called Cas9 seeks out a short region — called a protospacer adjacent motif (or PAM) — that is present in the viral DNA but not in the bacterial DNA. CRISPR-Cas9 has been harnessed for editing the human genome because such PAM sequences are also quite common in our DNA; however, genes that are not near a PAM cannot be targeted.To overcome this hurdle, a team led by Benjamin P. Kleinstiver, a biochemist at MGH’s Center for Genomic Medicine, engineered variants of a Cas9 protein that do not require a specific PAM to bind and cut DNA. The two new Cas9 variants, named SpG and SpRY, allow editing of DNA sequences at efficiencies not achievable with conventional CRISPR-Cas9 enzymes. A crisper CRISPR Related Genome editing with precision Radcliffe symposium examines the rapid advances brought by CRISPR “Because the engineered proteins can target much more freely, they enable targeting of previously inaccessible regions of the genome,” said Kleinstiver. “By nearly completely relaxing the requirement for the enzymes to recognize a PAM, many genome editing applications are now possible. And since nearly the entire genome is targetable, one of the most exciting implications is that that the entire genome is ‘druggable’ from a DNA-editing perspective.”The researchers next plan to better understand the mechanism of how these proteins function, while exploring their unique capabilities for a variety of different applications. In the meantime, they are optimistic that the new Cas9 variants will be a meaningful advance for the genome editing community.“We have demonstrated that these new enzymes will allow researchers to generate biologically and clinically relevant genetic modifications that were previously unfeasible.” said lead author Russell T. Walton, also of MGH’s Center for Genomic Medicine.Additional co-authors of the manuscript from the Kleinstiver laboratory include Kathleen A. Christie, and Madelynn N. Whittaker. Fewer off-target edits and greater targeting scope bring gene editing technology closer to treating human diseases Power and pitfalls of gene editing Prime editing system offers wide range of versatility in human cells, correcting disease-causing genetic variations last_img read more

Matic extends Man U contract until 2023

first_imgRelatedPosts Ighalo: My best moment as ‘Red Devil’ EPL: Crystal Palace stun sloppy Man U EPL: Red Devils attack Palace Manchester United midfielder Nemanja Matic has extended his contract with the club until June 2023.The Serbia international, 31, joined United from Chelsea in 2017 and was due to be out of contract in June of 2021. “As a player, I still have a lot more to give and achieve in my career and to do that with Manchester United will be a huge honour,” Matic said.“This is a really exciting team to be part of, we have a good balance of youth and experience within the squad.”Manager Ole Gunnar Solskjaer said he was “delighted” Matic has extended his deal, adding: “I know his experience, professionalism and leadership will be invaluable to this young talented group.“Nemanja has been here for three seasons now and really understands the values of playing for Manchester United.”Matic has played 27 times in all competitions for the club this season. Solskjaer’s side have not lost since January – a run of 16 games in all competitions – and sit fifth in the Premier League table.Tags: Contract ExtensionManchester UnitedNemanja Maticlast_img read more

Don’t let spring football game get your hopes up

first_imgDon’t make any judgments based on what happens Saturday.There are still more than 150 days until UW officially kicks off its season.Playing its annual spring football game at Camp RandallStadium this weekend, the football team will make its first appearance of 2008,giving fans an opportunity to gauge where the program stands heading into theupcoming season. Unfortunately, it also gives Badger supporters a chance tostart getting their hopes up (or down) about what awaits in the fall.Whether quarterback Allan Evridge throws for 300 yards orsafety Shane Carter intercepts four passes, it’s important to remember thatthere is still almost half a year before the team takes its first real snap ofthe season against Akron.Keep in mind that after the game last season, there wereplenty of good signs to focus on.Lance Smith, for one, looked like an all-conference runningback after rushing for 75 yards and a pair of touchdowns. Anyone expecting abreakout year from the sophomore was ultimately left disappointed, however, asSmith was suspended before the season started and ended up missing all five ofthe team’s regular season road games.The first string (cardinal) defense also offered plenty tobe excited about after giving up just six points in last year’s contest. Butonce the season began, it became apparent that stopping actual opponents wasgoing to be a problem and the unit was a major liability all season.As in all sports — but especially football, where injuriesare prevalent — things change. Players have good days and bad ones. They getbetter or start to struggle. There are injuries and suspensions.All of those things should be considered while watchingSaturday’s game, because the team that takes the field this weekend may notbear much resemblance to the one that does four months from now.Saturday is more than just a chance to see how AllanEvridge’s arm looks or if David Gilreath has gotten more explosive.In fact, if there are any conclusions worth making about thegame, they are more likely to be found in the stands instead of on the field.This season is a chance to measure where the Badgers areheaded in Bret Bielema’s critical third year at the helm. The spring game is anopportunity to see whether he still has the support of the fans.Bielema could do no wrong in his first year, going 12-1 andleading UW to a victory in the Capital One Bowl. Last season was a step back,though. Marked by several tough midseason losses, the Badgers finished the yearwith a disappointing 9-4 record and the coach’s image had taken a hit.Now, three years removed from Barry Alvarez, it’s put up orshut up time for Bielema, and what happens in the stands should indicate the confidencefans have in his ability to replace the legendary coach.In 2006, Bielema’s first year on the job, there were alittle more than 10,000 fans on hand for the spring game. Twelve wins later andthat number almost doubled to 18,020 for last year’s game.Coming off a down year, however, it will be interesting tosee what the crowd turnout is like. Have the fans started to lose faith inBielema? Do they stand by the head coach?This past Saturday, Florida packed in 60,000 fans, as wellas the College GameDay crew, for its spring game.Alabama, in its first season with Nick Saban, welcomed morethan 95,000 Crimson fans to see his team scrimmage last year.While Wisconsin probably wouldn’t approach those numberseven after a great season, if this year’s turnout is lower than last year’s, itisn’t a good sign for the coach.Of particular note will be the number of students inattendance, as well as their behavior.Bielema has been trying to get students to arrive at gamesearlier and earlier, and a good turnout Saturday probably means that morerespect is being shown to the head coach. Last season’s “Sea of Red”turned out to be a success, but with two more primetime games announced forthis year, the students will need to take another step in the right directionif fall Saturdays are going to have their focus shifted from drinking tofootball.While things can indeed change with the crowd between nowand the start of the season, it’s less likely to shift as dramatically as theteam’s level of play.In any event, both on the field and off, Saturday’s game isstill just a glorified practice. Nothing counts until August.?Mike is a sophomore majoring in political science. If youhave already jumped to conclusions about the game, or have other thoughts onthe team, he can be reached at [email protected]last_img read more